Back to Search
Start Over
Structure and Reversible Pyran Formation in Molybdenum Pyranopterin Dithiolene Models of the Molybdenum Cofactor
- Source :
- Journal of the American Chemical Society. 134:19584-19587
- Publication Year :
- 2012
- Publisher :
- American Chemical Society (ACS), 2012.
-
Abstract
- The syntheses and X-ray structures of two molybdenum pyranopterin dithiolene complexes in biologically relevant Mo(4+) and Mo(5+) states are reported. Crystallography reveals that these complexes possess a pyran ring formed through a spontaneous cyclization reaction of a dithiolene side-chain hydroxyl group at a C═N bond of the pterin. NMR data on the Mo(4+) complex suggest that a reversible pyran ring cyclization occurs in solution. These results provide experimental evidence that the pyranopterin dithiolene ligand in molybdenum and tungsten enzymes could participate in catalysis through dynamic processes modulated by the protein.
- Subjects :
- Models, Molecular
Stereochemistry
Coenzymes
chemistry.chemical_element
Crystallography, X-Ray
Ligands
Ring (chemistry)
Photochemistry
Biochemistry
Article
Catalysis
chemistry.chemical_compound
Colloid and Surface Chemistry
Metalloproteins
Organometallic Compounds
Pterin
Group 2 organometallic chemistry
Molybdenum
Ligand
Pteridines
General Chemistry
Pterins
chemistry
Cyclization
Pyran
Molybdenum cofactor
Molybdenum Cofactors
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 134
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....627551033e2ac5e270ecb0e08ea060d4