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Bicatalytic Multistep Reactions En Route to the One-Pot Total Synthesis of Complex Molecules: Easy Access to Chromene and 1,2-Dihydroquinoline Derivatives from Simple Substrates
- Source :
- ChemCatChem. 9:70-75
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- By combining nanocatalysis and base-catalysis, a novel one-pot multistep process was found for the synthesis of substituted heterocycles of biological relevance from simple substrates. It is based on an initial Au/O2 oxidation of allylic alcohols followed by a base-catalysed tandem hetero-Michael/aldolisation/crotonisation with ortho-hydroxy or ortho-amino benzaldehydes. The flexibility of the reaction even allowed the benzaldehyde partner to be prepared in situ in an example of one-pot/5-steps process.
- Subjects :
- Green chemistry
Allylic rearrangement
Tandem
010405 organic chemistry
Organic Chemistry
Total synthesis
010402 general chemistry
01 natural sciences
Catalysis
0104 chemical sciences
Inorganic Chemistry
Benzaldehyde
chemistry.chemical_compound
chemistry
Organic chemistry
Molecule
QD
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 18673880
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- ChemCatChem
- Accession number :
- edsair.doi.dedup.....6274cd46a8c3d5d4d6b4e6df9f9069b7