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The International Prognostic Scoring System does not accurately discriminate different risk categories in patients with post-essential thrombocythemia and post-polycythemia vera myelofibrosis

Authors :
Francisca Ferrer-Marín
Valentín García-Gutiérrez
Juan Carlos Hernández-Boluda
Ana Kerguelen
Elisa Luño
Elisa Arbelo
Concepción Boqué
Joaquin Martinez-Lopez
Blanca Xicoy
Carles Besses
Jesús Martínez
Pere Barba
Arturo Pereira
J. M. Raya
Montse Gómez
Alberto Alvarez-Larrán
Grupo Español de Enfermedades Mieloproliferativas Filadelfia Negativas (GEMFIN)
[Hernández-Boluda,JC
Gómez,M] Hematology and Medical Oncology Department, Hospital Clínico Universitario, Valencia, España. [Pereira,A] Hemotherapy and Hemostasis Department, Hospital Clínic, Barcelona, España. [Boqué,C] Hematology Department, Institut Català d’Oncologia, Hospitalet de Llobregat, Barcelona,España. [Ferrer-Marín,F] Hematology and Medical Oncology Department, Hospital Morales Meseguer, Murcia, España. [Raya,JM] Hematology Department, Hospital Universitario de Canarias, La Laguna, España. [García-Gutiérrez,V] Hematology Department, Hospital Ramón y Cajal, Madrid, España. [Kerguelen,A] Hematology Department, Hospital La Paz, Madrid, España. [Xicoy,B] Clinical Hematology Department, Institut Català d’Oncologia, Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research, Badalona, España. [Barba,P] Hematology Department, Hospital Vall d’Hebron, Barcelona, España. [Martínez,J] Hematology Department, Hospital La Fe, Valencia, España. [Luño,E] Hematology Department, Hospital Universitario Central de Asturias, Oviedo, España. [Alvarez-Larrán,A] Hematology Department, Hospital del Mar-IMIM, Barcelona España. [Arbelo,E] Hematology Department, Hospital 12 de Octubre, Madrid, España. [Besses,C] Hematology Department, Hospital Virgen de la Macarena, Sevilla, Spain.
Source :
RUO. Repositorio Institucional de la Universidad de Oviedo, instname
Publication Year :
2014
Publisher :
Ferrata Storti Foundation : The European Hematology Association, 2014.

Abstract

Myelofibrotic transformation is a well-recognized complication of essential thrombocythemia (ET) and polycythemia vera (PV).[1][1],[2][2] However, information is scarce on the life expectancy and prognostic factors of patients developing this complication.[1][1],[3][3]–[5][4] Prognostic models

Subjects

Subjects :
Oncology
medicine.medical_specialty
Survival
Prognostic factors
Mielofibrosis primaria
Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases::Myeloproliferative Disorders::Primary Myelofibrosis [Medical Subject Headings]
Risk category
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Polycythemia vera
Internal medicine
Post-ET myelofibrosis
medicine
Humans
In patient
Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation::Drive [Medical Subject Headings]
Myelofibrosis
Online Only Articles
Trombocitemia esencial
Polycythemia Vera
Prognostic models
ComputingMilieux_THECOMPUTINGPROFESSION
Essential thrombocythemia
business.industry
IPSS
Post-PV myelofibrosis
Policitemia vera
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Life Expectancy [Medical Subject Headings]
Hematology
Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Blood Coagulation Disorders::Thrombocythemia, Essential [Medical Subject Headings]
medicine.disease
Prognosis
Impulso
TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES
International Prognostic Scoring System
Primary Myelofibrosis
Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Janus Kinases::Janus Kinase 2 [Medical Subject Headings]
Janus quinasa 2
Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]
Complication
business
Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases::Myeloproliferative Disorders::Polycythemia Vera [Medical Subject Headings]
Thrombocythemia, Essential

Details

Language :
English
Database :
OpenAIRE
Journal :
RUO. Repositorio Institucional de la Universidad de Oviedo, instname
Accession number :
edsair.doi.dedup.....6269380f85645115431b8b92ac5349ff