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Cross-linked trimers of bovine ribonuclease A: activity on double-stranded RNA and antitumor action

Authors :
L. Testolin
Ubaldo Armato
Chiara Costanzo
Massimo Libonati
Salvatore Sorrentino
Giovanni Gotte
Gotte, G
Testolin, L
Costanzo, C
Sorrentino, Salvatore
Armato, U
Libonati, M.
Publication Year :
1997

Abstract

Trimers of bovine pancreatic RNase A were obtained by cross-linking native RNase A with dimethyl suberimidate. They degrade double-stranded RNA more efficiently than dimers and monomers of RNase A, and display significant cytotoxic and/or cytostatic actions against C4-I cells (a human cell line derived from squamous carcinoma of the uterus cervix). On the same cell line cross-linked dimers of RNase A appear to be ineffective.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....6265bd944bcdd6a481f935ea2fd02da3