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Surgical management of cerebral metastases from non-small cell lung cancer
- Source :
- Scopus-Elsevier
- Publication Year :
- 2003
-
Abstract
- Aims and Background The objective of the study was to assess the efficacy of surgical resection of solitary brain metastasis in patients with non-small-cell lung cancer. Methods and Study Design We report a retrospective analysis of 32 patients with single brain metastasis surgically excised at our hospital. All but one patient underwent postoperative whole brain radiation therapy. Results The median survival of patients was 12.5 months postoperatively (mean, 17 months), and the overall 1-year survival was 53%. Thirteen patients had recurrence of brain metastasis: 6 of 13 underwent reoperation for the recurrent lesion, and 1 of the 6 patients had a third craniotomy. Baseline characteristics, which significantly influenced survival, included age less than 60 years, tumor histology (ie, adenocarcinoma), and treatment of the primary lung cancer. The analysis did not yield any significant differences between treatment modalities. Conclusions Our findings correspond well with those reported in the literature and suggest that surgical resection of single brain metastasis in patients with non-small cell lung cancer can improve survival over conservative management. Furthermore, surgical treatment of the primary tumor and the single brain metastasis, combined or not with radiotherapy and chemotherapy, represents an approach that merits further investigation with more patients and a prospective longitudinal design.
- Subjects :
- Adult
Male
Reoperation
Cancer Research
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
Antineoplastic Agents
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Lung cancer
Craniotomy
Aged
Retrospective Studies
Chemotherapy
business.industry
Brain Neoplasms
Retrospective cohort study
Radiotherapy Dosage
General Medicine
Middle Aged
medicine.disease
Primary tumor
Combined Modality Therapy
Surgery
Radiation therapy
Survival Rate
Oncology
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Cranial Irradiation
Neoplasm Recurrence, Local
business
Tomography, X-Ray Computed
Brain metastasis
Follow-Up Studies
Subjects
Details
- ISSN :
- 03008916
- Volume :
- 89
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Tumori
- Accession number :
- edsair.doi.dedup.....62631847bfdd5354443012664be6ae9d