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Treatment with antidepressive drugs improved quality of life in chronic hemodialysis patients
- Source :
- Clinical nephrology. 65(2)
- Publication Year :
- 2006
-
Abstract
- BACKGROUND Despite some improvements in dialysis therapies, depression still remains an important problem in chronic hemodialysis (HD) patients. In this study, we aimed to investigate the association of depression and its treatment with quality of life (QOL) in HD patients. PATIENTS AND METHODS 97 HD patients (52 male, 45 female, mean age 55 +/- 16 years) were enrolled. All patients had been dialyzed for more than 6 months. In order to evaluate QOL of the patients, a short form of Medical Outcomes Study (SF-36) was used. Depression was assessed by using Beck Depression Inventory (BDI). Patients who had BDI score > or = 15 were diagnosed as to have depression. Patients with depression received antidepressive treatment (sertralin HCl, 50 mg/day) for an 8-week period. After 8-week antidepressive treatment, all biochemical analysis, SF-36 and BDI were performed again. RESULTS 40 patients (20 male, 20 female, mean age 56 +/- 14 years) had depression. All parameters related to QOL were significantly decreased in patients with depression as compared to patients without depression. Severity of depression was correlated with QOL parameters. After 8 weeks of treatment, as parallel to changes in BDI, QOL parameters improved in patients with depression. CONCLUSION Decrease in QOL, associated with depression and antidepressive treatment, improves QOL in HD patients. Hemodialysis patients should be followed-up closely for presence of depression. Treatment of depression with antidepressive drug regimen would lead to relieve the symptoms related to depression and improvement of QOL in these patients. Antidepressive treatment should be required more often than we prescribe in routine clinical practice now.
- Subjects :
- Nephrology
Male
medicine.medical_specialty
SF-36
medicine.medical_treatment
Statistics, Nonparametric
Quality of life
Renal Dialysis
Internal medicine
Medicine
Humans
Depression (differential diagnoses)
Dialysis
Chemotherapy
Analysis of Variance
business.industry
Depression
Beck Depression Inventory
General Medicine
Middle Aged
humanities
Antidepressive Agents
Treatment Outcome
Physical therapy
Quality of Life
Kidney Failure, Chronic
Female
Hemodialysis
business
Subjects
Details
- ISSN :
- 03010430
- Volume :
- 65
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical nephrology
- Accession number :
- edsair.doi.dedup.....625ce33ee8215b39c8c0c3858ea15558