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A strain-variable bacteriocin in Bacillus anthracis and Bacillus cereus with repeated Cys-Xaa-Xaa motifs
- Source :
- Biology Direct, Vol 4, Iss 1, p 15 (2009), Biology Direct
- Publication Year :
- 2009
- Publisher :
- BMC, 2009.
-
Abstract
- Bacteriocins are peptide antibiotics from ribosomally translated precursors, produced by bacteria often through extensive post-translational modification. Minimal sequence conservation, short gene lengths, and low complexity sequence can hinder bacteriocin identification, even during gene calling, so they are often discovered by proximity to accessory genes encoding maturation, immunity, and export functions. This work reports a new subfamily of putative thiazole-containing heterocyclic bacteriocins. It appears universal in all strains of Bacillus anthracis and B. cereus, but has gone unrecognized because it is always encoded far from its maturation protein operon. Patterns of insertions and deletions among twenty-four variants suggest a repeating functional unit of Cys-Xaa-Xaa. Reviewers This article was reviewed by Andrei Osterman and Lakshminarayan Iyer.
- Subjects :
- Subfamily
Operon
Amino Acid Motifs
Molecular Sequence Data
Immunology
Bacillus cereus
Sequence alignment
General Biochemistry, Genetics and Molecular Biology
Microbiology
Bacteriocins
Species Specificity
Bacteriocin
Cysteine
Discovery Notes
Gene
lcsh:QH301-705.5
Ecology, Evolution, Behavior and Systematics
Genetics
Agricultural and Biological Sciences(all)
biology
Biochemistry, Genetics and Molecular Biology(all)
Applied Mathematics
biology.organism_classification
Bacillus anthracis
Cereus
lcsh:Biology (General)
Modeling and Simulation
bacteria
General Agricultural and Biological Sciences
Sequence Alignment
Subjects
Details
- Language :
- English
- ISSN :
- 17456150
- Volume :
- 4
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biology Direct
- Accession number :
- edsair.doi.dedup.....62557aabb8a3b7db18eb4eb7c75d4433