Back to Search
Start Over
An innovative biologic system for photon-powered myocardium in the ischemic heart
- Source :
- Science Advances
- Publication Year :
- 2016
-
Abstract
- Solar-powered heart? Harnessing light to create myocardial renewable energy.<br />Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus. By using light rather than blood flow as a source of energy, photosynthetic therapy increases tissue oxygenation, maintains myocardial metabolism, and yields durable improvements in cardiac function during and after induction of ischemia. By circumventing blood flow entirely to provide tissue with oxygen and nutrients, this system has the potential to create a paradigm shift in the way ischemic heart disease is treated.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
Physics::Medical Physics
Myocardial Ischemia
030204 cardiovascular system & hematology
Quantitative Biology::Cell Behavior
Coronary artery disease
0302 clinical medicine
Astrophysics::Solar and Stellar Astrophysics
Myocytes, Cardiac
Myocardial infarction
Photosynthesis
Hypoxia
Research Articles
Multidisciplinary
ischemic cardiomyopathy
SciAdv r-articles
Synechococcus elongatus
Heart
tissue ischemia
3. Good health
Biological Therapy
Phototrophic Processes
myocardial infarction
Physics::Space Physics
Heart Function Tests
Cardiology
medicine.symptom
coronary artery disease
Research Article
Cardiac function curve
medicine.medical_specialty
Quantitative Biology::Tissues and Organs
Ischemia
Revascularization
Cyanobacteria
03 medical and health sciences
Internal medicine
medicine
Humans
Regeneration
Animals
Health and Medicine
Symbiosis
bioengineering
Ischemic cardiomyopathy
business.industry
Myocardium
Hypoxia (medical)
medicine.disease
ischemic heart disease
Rats
Oxygen
030104 developmental biology
Heart failure
business
Energy Metabolism
Subjects
Details
- ISSN :
- 23752548
- Volume :
- 3
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Science advances
- Accession number :
- edsair.doi.dedup.....624985c70e2afe4e0fb9c8fe7e190ba7