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Potential neuroprotective effects of heat-killed Lactococcus lactis KC24 using SH-SY5Y cells against oxidative stress induced by hydrogen peroxide
- Source :
- Food Sci Biotechnol
- Publication Year :
- 2020
- Publisher :
- Springer Singapore, 2020.
-
Abstract
- The present study was an investigation of the neuroprotective effects of probiotic bacteria in SH-SY5Y neuroblastoma cells experiencing oxidative stress. The bacterial strains were: commercial Lactobacillus rhamnosus GG; two isolated bacterial strains (Lactobacillus delbrueckii KU200170 and Lactobacillus plantarum KU200661); and probiotic Lactococcus lactis KC24. To evaluate the neuroprotective effects of the bacteria, a conditioned medium (CM) was prepared using HT-29 cells cultured with the heat-killed probiotic strains. Of the bacterial strains tested, the oxidatively stressed SH-SY5Y cells were most viable when cultured with L. lactis KC24-CM. L. lactis KC24-CM promoted the expression of brain-derived neurotropic factor (BDNF) in the HT-29 cells. It also significantly increased BDNF expression and reduced the apoptosis-related Bax/Bcl-2 ratio in the oxidatively stressed SH-SY5Y cells. Therefore, L. lactis KC24 is a potential psychobiotic for use in the functional food industry.
- Subjects :
- 0106 biological sciences
SH-SY5Y
medicine.disease_cause
01 natural sciences
Applied Microbiology and Biotechnology
Article
law.invention
Microbiology
Probiotic
0404 agricultural biotechnology
Lactobacillus rhamnosus
law
010608 biotechnology
Lactobacillus
medicine
biology
Chemistry
Lactococcus lactis
food and beverages
04 agricultural and veterinary sciences
biology.organism_classification
040401 food science
Lactobacillus plantarum
Oxidative stress
Bacteria
Food Science
Biotechnology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Food Sci Biotechnol
- Accession number :
- edsair.doi.dedup.....6235f77bd0a644fd9e6657522c6ff079