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Prevalence and clinical characteristics of non-alcoholic fatty liver disease in newly diagnosed patients with ketosis-onset diabetes
- Source :
- Diabetesmetabolism. 44(5)
- Publication Year :
- 2017
-
Abstract
- As the prevalence and clinical characteristics of non-alcoholic fatty liver disease (NAFLD) are still unknown in ketosis-onset diabetes, the present study compared the characteristics of NAFLD in type 1 diabetes (T1D), ketosis-onset and non-ketotic type 2 diabetes (T2D) patients.This cross-sectional study was performed with newly diagnosed Chinese patients with diabetes, including 39 T1D, 165 ketosis-onset and 173 non-ketotic T2D, with 30 non-diabetics included as controls. NAFLD was determined by hepatic ultrasonography, then its clinical features were analyzed and its associated risk factors evaluated.NAFLD prevalence in patients with ketosis-onset diabetes (61.8%) was significantly higher than in controls (23.3%; P=0.003) and in T1D patients (15.4%; P0.001). However, there was no difference in prevalence between ketosis-onset and non-ketotic T2D patients (52.6%; P=0.229), although BMI and alanine aminotransferase (ALT) proved to be independent risk factors for the presence of NAFLD in both these groups whereas, in T1D patients, serum uric acid levels were independent risk factors.NAFLD prevalence and risk factors in ketosis-onset diabetes were similar to those in non-ketotic T2D, but different from those in T1D. These data provide further evidence that ketosis-onset diabetes should be classified as a subtype of T2D rather than idiopathic T1D.
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
Disease
Newly diagnosed
Comorbidity
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Non-alcoholic Fatty Liver Disease
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Prevalence
Humans
Aged
Type 1 diabetes
business.industry
Fatty liver
nutritional and metabolic diseases
Non alcoholic
General Medicine
Middle Aged
medicine.disease
Uric Acid
Cross-Sectional Studies
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
030211 gastroenterology & hepatology
Female
Ketosis
business
Subjects
Details
- ISSN :
- 18781780
- Volume :
- 44
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Diabetesmetabolism
- Accession number :
- edsair.doi.dedup.....622f06512690133ece5cda1c3fb819b1