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Systems biology of infectious diseases: a focus on fungal infections
- Source :
- Immunobiology, Immunobiology, Elsevier, 2011, 216 (11), pp.1212-27. ⟨10.1016/j.imbio.2011.08.004⟩, Immunobiology, 2011, 216 (11), pp.1212-27. ⟨10.1016/j.imbio.2011.08.004⟩
- Publication Year :
- 2011
-
Abstract
- International audience; The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources.
- Subjects :
- Proteomics
Antifungal Agents
MESH: Th17 Cells
Disease
MESH: Drug Design
Bioinformatics
MESH: Receptors, Pattern Recognition
MESH: Molecular Targeted Therapy
Candida albicans
Immunology and Allergy
MESH: Animals
MESH: Immune Evasion
MESH: Genetic Variation
Molecular Targeted Therapy
Organism
MESH: Cytokines
0303 health sciences
MESH: Proteomics
Systems Biology
Hematology
3. Good health
Drug development
MESH: Systems Biology
Receptors, Pattern Recognition
MESH: Genome, Fungal
Host-Pathogen Interactions
MESH: Communicable Diseases
[SDV.IMM]Life Sciences [q-bio]/Immunology
Cytokines
MESH: Aspergillus fumigatus
Genome, Fungal
MESH: Immune Tolerance
Systems biology
Host–pathogen interaction
Immunology
Computational biology
Biology
Communicable Diseases
Underlying infection
03 medical and health sciences
MESH: Mycoses
Immune Tolerance
Animals
Humans
Immune Evasion
030304 developmental biology
MESH: Humans
030306 microbiology
MESH: Candida albicans
Aspergillus fumigatus
MESH: Host-Pathogen Interactions
MESH: Biological Markers
Genetic Variation
Th1 Cells
MESH: Antifungal Agents
Microarray Analysis
MESH: Microarray Analysis
MESH: Th1 Cells
Mycoses
Infectious disease (medical specialty)
Drug Design
Th17 Cells
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 01712985
- Database :
- OpenAIRE
- Journal :
- Immunobiology, Immunobiology, Elsevier, 2011, 216 (11), pp.1212-27. ⟨10.1016/j.imbio.2011.08.004⟩, Immunobiology, 2011, 216 (11), pp.1212-27. ⟨10.1016/j.imbio.2011.08.004⟩
- Accession number :
- edsair.doi.dedup.....621f5b8e7abfc63693aa788c56d16df0