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Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome
- Source :
- Biomarkers, 19(7), 611-619. Informa Healthcare
- Publication Year :
- 2014
-
Abstract
- Objective: To investigate relations of several circulating chemokines with extent and phenotype of coronary atherosclerosis and with 1-year clinical outcome. Methods: Intravascular ultrasound virtual histology (IVUS-VH) imaging of a coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), MIP-1β and regulated upon activation normal T cell expressed and secreted (RANTES) were measured in plasma. Results: Higher MCP-1, MIP-1α and lower RANTES were associated with coronary plaque burden. Higher MCP-1, MIP-1α and lower RANTES were associated with the presence of IVUS-VH-derived thin-cap fibroatheroma lesions. RANTES was associated with major adverse cardiac events. Conclusions: RANTES is a promising biomarker that is inversely associated with coronary plaque burden and vulnerability, as well as with death and acute coronary syndrome. Trial registration:ClinicalTrials.gov identifier: NCT01789411.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Acute coronary syndrome
Chemokine
Time Factors
Health, Toxicology and Mutagenesis
Clinical Biochemistry
Coronary Artery Disease
Kaplan-Meier Estimate
Biochemistry
Necrosis
Predictive Value of Tests
Internal medicine
Intravascular ultrasound
medicine
Macrophage
Humans
Prospective Studies
Chemokine CCL4
Chemokine CCL5
Coronary atherosclerosis
Chemokine CCL2
Ultrasonography, Interventional
Aged
Chemokine CCL3
medicine.diagnostic_test
biology
business.industry
Monocyte
Middle Aged
medicine.disease
Prognosis
Coronary Vessels
Fibrosis
Plaque, Atherosclerotic
medicine.anatomical_structure
Cardiology
biology.protein
Biomarker (medicine)
Female
Chemokines
business
Biomarkers
Artery
Subjects
Details
- ISSN :
- 1354750X
- Volume :
- 19
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Biomarkers
- Accession number :
- edsair.doi.dedup.....6216c078e8f13bc06976ad38c6ba9dc7