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Fabrication of combined-scale nano- and microfluidic polymer systems using a multilevel dry etching, electroplating and molding process
- Source :
- Technical University of Denmark Orbit
- Publication Year :
- 2012
- Publisher :
- IOP Publishing, 2012.
-
Abstract
- Microfabricated single-cell capture and DNA stretching devices have been produced by injection molding. The fabrication scheme employed deep reactive ion etching in a silicon substrate, electroplating in nickel and molding in cyclic olefin polymer. This work proposes technical solutions to fabrication challenges associated with chip sealing and demolding of polymer high-volume replication methods. UV-assisted thermal bonding was found to ensure a strong seal of the microstructures in the molded part without altering the geometry of the channels. In the DNA stretching device, a low aspect ratio nanoslit (1/200) connecting two larger micro-channels was used to stretch a 168.5 kbp DNA molecule, while in the other device single-HeLa cells were captured against a micro-aperture connecting two larger microfluidic channels. Different dry etching processes have been investigated for the master origination of the cell-capture device. The combination of a modified Bosch process and an isotropic polysilicon etch was found to ensure the ease of demolding by resulting in slightly positively tapered sidewalls with negligible undercut at the mask interface. (Some figures may appear in colour only in the online journal)
- Subjects :
- chemistry.chemical_classification
Fabrication
Materials science
business.industry
Mechanical Engineering
Microfluidics
Nanotechnology
Polymer
Molding (process)
Electronic, Optical and Magnetic Materials
chemistry
Mechanics of Materials
Deep reactive-ion etching
Optoelectronics
Undercut
Dry etching
Electrical and Electronic Engineering
business
Electroplating
Subjects
Details
- ISSN :
- 13616439 and 09601317
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Micromechanics and Microengineering
- Accession number :
- edsair.doi.dedup.....6212935e855dab8b91eb583ec4cdc40a