Back to Search
Start Over
Prognosis Following Acute Exacerbation of COPD Treated With Non-invasive Mechanical Ventilation
- Source :
- Archivos de Bronconeumología ((English Edition)). 46:405-410
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Introduction Patients with chronic obstructive pulmonary disease (COPD) who survived an acute exacerbation with acute respiratory failure that required non-invasive mechanical ventilation (NIMV) are a group with a poor medium-term prognosis. Objective To identify re-admission and mortality rates within one year from discharge and to analyse factors associated with both events in a consecutive series of COPD patients treated with NIMV. Methods A cohort of 93 COPD patients who survived an acute exacerbation and who required NIMV was followed up after discharge. Re-admissions due to respiratory causes and survival were measured and the outcomes were analysed against possible factors associated to such events using multivariate Cox proportional risk regression analysis. Results Over the year following discharge, 61 patients (66 %) had to be re-admitted into hospital due to respiratory complications. Upon multivariate analysis, a low FEV 1 value in stable phase and a high average length of stay were associated independently with a high risk of hospital readmission. The probability of survival at 1 year was 0.695. Age, PaCO 2 prior to initiation of NIMV and the number of hospitalisation days in the previous year were associated independently with a high mortality risk. Conclusions This group of COPD patients has a high mortality rate and need for re-hospitalisation in the ensuing year following discharge. The variables relating to the severity of the baseline disease and the actual exacerbation have been shown to be associated with these events, and could be applied to this subgroup of patients in specific follow-up programs.
- Subjects :
- Male
medicine.medical_specialty
Exacerbation
medicine.medical_treatment
Severity of Illness Index
Positive-Pressure Respiration
Pulmonary Disease, Chronic Obstructive
Internal medicine
Severity of illness
medicine
Humans
Prospective Studies
Prospective cohort study
Survival rate
Aged
Mechanical ventilation
COPD
business.industry
Mortality rate
General Medicine
Prognosis
medicine.disease
Survival Rate
Acute Disease
Cohort
Female
business
Subjects
Details
- ISSN :
- 15792129
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Archivos de Bronconeumología ((English Edition))
- Accession number :
- edsair.doi.dedup.....620cabc2ca8c121d8b04479f7a5c4a07