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Gold thread implantation promotes hair growth in human and mice
- Source :
- Laboratory Animal Research, Laboratory Animal Research, Vol 33, Iss 4, Pp 291-297 (2018)
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains largely unknown due to lack of investigation. When we implanted gold thread and Happy Lift™ in human patient for facial lifting, we unexpectedly found an increase of hair regrowth in spite of no use of hair growth medications. When embedded into the depilated dorsal skin of mice, gold thread or polyglycolic acid (PGA) thread, similarly to 5% minoxidil, significantly increased the number of hair follicles on day 14 after implantation. And, hair re-growth promotion in the gold threadimplanted mice were significantly higher than that in PGA thread group on day 11 after depilation. In particular, the skin tissue of gold thread-implanted mice showed stronger PCNA staining and higher collagen density compared with control mice. These results indicate that gold thread implantation can be an effective way to promote hair re-growth although further confirmatory study is needed for more information on therapeutic mechanisms and long-term safety.
- Subjects :
- Dorsum
hair loss
Connective tissue
Andrology
Hair growth
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
hair growth
Skin tissue
medicine
lcsh:QH301-705.5
lcsh:R5-920
integumentary system
Human patient
food and beverages
medicine.disease
Skin tightening
Hair loss
medicine.anatomical_structure
lcsh:Biology (General)
Minoxidil
030220 oncology & carcinogenesis
Original Article
Gold thread
lcsh:Medicine (General)
medicine.drug
Subjects
Details
- ISSN :
- 22337660 and 17386055
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Laboratory Animal Research
- Accession number :
- edsair.doi.dedup.....61f9e82614bff816826a7ca3dce70c05