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Next-Generation Probiotics for Inflammatory Bowel Disease
- Source :
- International Journal of Molecular Sciences. 23:5466
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Engineered probiotics represent a cutting-edge therapy in intestinal inflammatory disease (IBD). Genetically modified bacteria have provided a new strategy to release therapeutically operative molecules in the intestine and have grown into promising new therapies for IBD. Current IBD treatments, such as corticosteroids and immunosuppressants, are associated with relevant side effects and a significant proportion of patients are dependent on these therapies, thus exposing them to the risk of relevant long-term side effects. Discovering new and effective therapeutic strategies is a worldwide goal in this research field and engineered probiotics could potentially provide a viable solution. This review aims at describing the proceeding of bacterial engineering and how genetically modified probiotics may represent a promising new biotechnological approach in IBD treatment.
- Subjects :
- bioengineering
Bacteria
Organic Chemistry
General Medicine
Inflammatory Bowel Diseases
biosensor
biosensors
Catalysis
Intestine
Computer Science Applications
Intestines
Inorganic Chemistry
probiotics
biotherapeutic
inflammatory bowel disease
Chronic Disease
biotherapeutics
Humans
Physical and Theoretical Chemistry
Molecular Biology
probiotic
Spectroscopy
Human
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....61f86e38893c40f11a959d6895ecd651
- Full Text :
- https://doi.org/10.3390/ijms23105466