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Non-steroidal anti-inflammatory drugs and the risk of out-of-hospital cardiac arrest: a case-control study
- Source :
- Bakhriansyah, M, Souverein, P C, Klungel, O H, De Boer, A, Blom, M T & Tan, H L 2019, ' Non-steroidal anti-inflammatory drugs and the risk of out-of-hospital cardiac arrest : A case-control study ', Europace, vol. 21, no. 1, pp. 99-105 . https://doi.org/10.1093/europace/euy180, Europace : European pacing, arrhythmias, and cardiac electrophysiology, 21(1), 99-105. Oxford University Press, Europace, Europace, 21(1), 99-105. Oxford University Press, EP Europace, Europace, 21(1), 99. Oxford University Press
- Publication Year :
- 2019
-
Abstract
- Aims Non-steroidal anti-inflammatory drugs (NSAIDs), particularly selective COX-2 inhibitors, are associated with an in-creased risk of cardiovascular adverse events. However, the association between these drugs and out-of-hospitalcardiac arrest with electrocardiogram-documented ventricular tachycardia/ventricular fibrillation (VT/VF-OHCA)has not been studied yet. This study was aimed to evaluate the association between the use of selective COX-2inhibitors or conventional NSAIDs and VT/VF-OHCA compared with non-use .................................................................................................................................................................................................... Methods and results A case–control study was conducted among 2483 cases with VT/VF-OHCA from the AmsteRdam REsuscitationSTudies (ARREST) registry, an ongoing Dutch registry of OHCA, and 10 441 non-VT/VF-OHCA-controls from theDutch PHARMO Database Network, containing drug dispensing records of community pharmacies, over the pe-riod July 2005–December 2011. Up to five controls were matched for age and sex to one case at the date of VT/VF-OHCA (index date). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logis-tic regression analysis. Of the cases, 0.5% was currently exposed at the index date to selective COX-2 inhibitorsand 2.5% to conventional NSAIDs. Neither current use of selective COX-2 inhibitors nor conventional NSAIDs were associated with an increased risk of VT/VF-OHCA (adjusted OR 1.11, 95% CI: 0.79–1.56 and adjusted OR0.97, 95% CI: 0.86–1.10, respectively) compared with non-use. Stratification for VT/VF-OHCA with presence/ab-sence of acute myocardial infarction did not change these results .................................................................................................................................................................................................... Conclusion Exposure to selective COX-2 inhibitors or conventional NSAIDs was not associated with an increased risk of VT/VF-OHCA compared with non-use.
- Subjects :
- Male
Resuscitation
medicine.medical_specialty
030204 cardiovascular system & hematology
Ventricular tachycardia
Risk Assessment
Selective COX-2 inhibitors
03 medical and health sciences
0302 clinical medicine
Clinical Research
Risk Factors
Physiology (medical)
Internal medicine
Conventional NSAIDs
medicine
Humans
Sudden death and ICDs
Registries
030212 general & internal medicine
Myocardial infarction
Ventricular fibrillation
Adverse effect
Aged
Netherlands
Aged, 80 and over
Out-of-hospital cardiac arrest
Cyclooxygenase 2 Inhibitors
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Case-control study
Odds ratio
Middle Aged
Prognosis
medicine.disease
3. Good health
Case-Control Studies
Tachycardia, Ventricular
Female
Corrigendum
Cardiology and Cardiovascular Medicine
Risk assessment
business
Non-steroidal anti-inflammatory drugs
Subjects
Details
- Language :
- English
- ISSN :
- 10995129
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Europace : European pacing, arrhythmias, and cardiac electrophysiology
- Accession number :
- edsair.doi.dedup.....61f6680260eb0e7d98c15b36cd16f43c