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Antiretroviral blood levels in HIV/HCV-coinfected patients with cirrhosis after liver transplant: a report of three cases
- Source :
- Transplant Infectious Disease. 17:147-153
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Since the introduction of combined antiretroviral therapy, human immunodeficiency virus (HIV) infection is no longer a contraindication for solid organ transplantation. In HIV/hepatitis C virus (HCV)-coinfected patients undergoing liver transplantation, HCV-related cirrhosis, drug-drug interactions, and calcineurin inhibitors-related toxicity affect clinical outcomes. Therapeutic drug monitoring can be useful to assess antiretroviral over- or underexposure in this cohort. We report the clinical characteristics along with antiretroviral trough levels of maraviroc, darunavir, and etravirine in 3 HIV/HCV-coinfected liver transplant recipients who developed post-transplant liver cirrhosis.
- Subjects :
- Liver Cirrhosis
Male
Cirrhosis
medicine.medical_treatment
Etravirine
HIV Infections
Liver transplantation
Gastroenterology
Maraviroc
chemistry.chemical_compound
HIV Infection
Antiretrovirals
C-ART
HIV/HCV coinfection
Liver transplant
Therapaeutic drug monitoring
Transplantation
Infectious Diseases
Darunavir
Coinfection
virus diseases
Hepatitis C
Middle Aged
Pyridazines
Anti-Retroviral Agents
Female
Drug Monitoring
Pyridazine
Human
medicine.drug
medicine.medical_specialty
Liver Cirrhosi
Cyclohexanes
Cyclohexane
Internal medicine
Nitriles
medicine
Humans
Cirrhosi
business.industry
Triazoles
medicine.disease
Antiretroviral
Liver Transplantation
Pyrimidines
chemistry
Immunology
Anti-Retroviral Agent
business
Subjects
Details
- ISSN :
- 13982273
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Transplant Infectious Disease
- Accession number :
- edsair.doi.dedup.....61f013ae9d92fd89125ef6c033083d46