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Emergence of reticuloendotheliosis virus in pigeons in Guangdong Province, Southern China
- Source :
- Archives of virology. 161(7)
- Publication Year :
- 2015
-
Abstract
- Reticuloendotheliosis virus (REV), an important immunosuppressive pathogen, has many hosts, including chickens, ducks, geese, turkeys, and wild birds. Clinically, REV may lead to increased susceptibility to other pathogens, resulting in serious tissue damage (especially tumors) and the death of its host. In this study, we encountered a disease outbreak resulting in a large number of deaths of pigeons in Guangdong Province, Southern China. Histopathological analysis revealed apparent tumor-like lesions in multiple organs of pigeons. PCR assays for detection of tumor-associated pathogens (REV, avian leukosis virus, and Marek's disease virus) in poultry revealed the presence of REV sequences only. Moreover, fowlpox virus (FPV) with an insertion of REV long terminal repeat (LTR) sequences was also considered, but it was excluded using a specific PCR assay. To gain more genetic information, two full-length REV genome sequences were determined and found to have the highest nucleotide sequence similarity (99.9 %) and the closest genetic relationship to a vaccine strain (MD-2) and had a more distant genetic relationship (94.3 %) to a duck-origin strain (ATCC-VR775). To confirm the presence of REVs in pigeons, specific-pathogen-free (SPF) chickens and healthy pigeons were inoculated with microfiltered tumor tissue homogenates and were found to be susceptible to infection with REV. To our knowledge, this is the first report of REV in pigeons, and the data suggest that pigeons may be the natural host of REV.
- Subjects :
- 0301 basic medicine
China
040301 veterinary sciences
viruses
Genome, Viral
Biology
Virus
0403 veterinary science
03 medical and health sciences
Virology
Animals
Columbidae
Pathogen
Phylogeny
Poultry Diseases
Reticuloendotheliosis virus
Host (biology)
Bird Diseases
Nucleic acid sequence
Outbreak
04 agricultural and veterinary sciences
General Medicine
Fowlpox virus
Long terminal repeat
030104 developmental biology
Ducks
Chickens
Subjects
Details
- ISSN :
- 14328798
- Volume :
- 161
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Archives of virology
- Accession number :
- edsair.doi.dedup.....61ed9f5321786a7a7e19ddb744e0e143