Response to Comment on Buckley et al. Intensive Versus Standard Blood Pressure Control in SPRINT-Eligible Participants of ACCORD-BP. Diabetes Care 2017;40:1733-1738

Drs. Mi and Mukamal (1) have recently proposed an additional interpretation of the discrepant results of the Systolic Blood Pressure Intervention Trial (SPRINT) and the Action to Control Cardiovascular Risk in Diabetes Blood Pressure (ACCORD-BP) trial. Although we continue to support our conclusions that SPRINT-eligible ACCORD-BP participants benefited from intensive blood pressure lowering, we recognize that our results do not exclude the important contributions from other factors as explanations for the discrepant results of ACCORD-BP and SPRINT (2). Indeed, several alternative hypotheses have been proposed in an attempt to explain the discordant results of SPRINT and ACCORD-BP (3,4). We therefore welcome the contributions by Mi …