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Occult hepatitis C virus infection in patients with malignant lymphoproliferative disorders
- Source :
- International Journal of Immunopathology and Pharmacology
- Publication Year :
- 2020
-
Abstract
- Despite the link between HCV and malignant lymphoproliferative disorders has been established, the association between occult hepatitis C virus infection and malignant lymphoproliferative disorders remains obscure. The present study intended to identify the possible association between occult HCV infection and malignant lymphoproliferative disorders. Newly diagnosed patients with LPDs were screened for the presence of HCV-RNA in both plasma and PBMCs. PBMCs of the subjects were also, examined by transmission and immuno-electron microscopy. LPD patients showed a high percentage of HCV infection (71.9%): OCI-HCV (37.5%) and HCV (34.38%). Meanwhile, 28.13% of LPD patients did not show any evidence of HCV infection. Ultrastructural examination of PBMCs revealed the presence of intracytoplasmic vacuoles enclosing viral like particles, which were less prominent in occult HCV patients. The possibility of occult HCV should be considered in patients with LPDs which can be helpful in the management of the treatment protocol in order to set up a balance between the control of the tumor progression and minimizing post chemotherapy complications related to HCV infection.
- Subjects :
- 0301 basic medicine
Adult
Male
hepatitis C virus
medicine.medical_specialty
Hepatitis C virus
Immunology
Lymphoproliferative disorders
Newly diagnosed
Hepacivirus
medicine.disease_cause
Real-Time Polymerase Chain Reaction
Gastroenterology
Peripheral blood mononuclear cell
03 medical and health sciences
0302 clinical medicine
Microscopy, Electron, Transmission
Internal medicine
medicine
Immunology and Allergy
Humans
In patient
Original Research Article
Microscopy, Immunoelectron
Aged
Pharmacology
Aged, 80 and over
lymphoproliferative disorders
business.industry
Transmission (medicine)
occult HCV
virus diseases
Middle Aged
Viral Load
medicine.disease
Occult
Hepatitis C
digestive system diseases
030104 developmental biology
Tumor progression
Case-Control Studies
Hematologic Neoplasms
Leukocytes, Mononuclear
RNA, Viral
030211 gastroenterology & hepatology
Female
business
Subjects
Details
- ISSN :
- 20587384
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- International journal of immunopathology and pharmacology
- Accession number :
- edsair.doi.dedup.....61e26cacaf69f9808ba8a280e05ce226