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Supplementary Tables S1-S4 from Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models

Authors :
Darren A.E. Cross
William Pao
Brian Dougherty
Kenneth S. Thress
Garry Beran
Jonathan R. Dry
Paul D. Smith
Henry Brown
Claire H. Barnes
Elizabeth L. Christey O'Brien
Laura E. Ratcliffe
Ambar Ahmed
Miika J. Ahdesmaki
Sarah J. Ross
Eiki Ichihara
Paula Spitzler
Catherine B. Meador
Paul R. Fisher
Zhongwu Lai
Katherine J. Al-Kadhimi
Aleksandra A. Markovets
Daniel Stetson
Catherine A. Eberlein
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplementary Tables S1-S4. Generation of resistant cell populations (S1); Small molecule inhibitors (S2); IC50 (µM) values from cell growth inhibition assays comparing compound sensitivity between parental and resistant cell populations (S3); Genetic analysis of resistant cell populations (S4).

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....61ddc42520c3270386638ee0395982e2
Full Text :
https://doi.org/10.1158/0008-5472.22405283.v1