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Multi-modal imaging using a cascaded microscope design

Authors :
Xi Yang
Mark Harfouche
Kevin C. Zhou
Lucas Kreiss
Shiqi Xu
Pavan Chandra Konda
Kanghyun Kim
Roarke Horstmeyer
Source :
Optics Letters. 48:1658
Publication Year :
2023
Publisher :
Optica Publishing Group, 2023.

Abstract

We present a multi-modal fiber array snapshot technique (M-FAST) based on an array of 96 compact cameras placed behind a primary objective lens and a fiber bundle array. Our technique is capable of large-area, high-resolution, multi-channel video acquisition. The proposed design provides two key improvements to prior cascaded imaging system approaches: a novel optical arrangement that accommodates the use of planar camera arrays, and a new ability to acquire multi-modal image data acquisition. M-FAST is a multi-modal, scalable imaging system that can acquire snapshot dual-channel fluorescence images as well as differential phase contrast measurements over a large 6.59 mm × 9.74 mm field-of-view at 2.2-μm center full-pitch resolution.

Details

ISSN :
15394794 and 01469592
Volume :
48
Database :
OpenAIRE
Journal :
Optics Letters
Accession number :
edsair.doi.dedup.....61d8aa3ada0cd0b561e55c0c0360db74