Back to Search
Start Over
Galectin-3 Is a Potential Mediator for Atherosclerosis
- Source :
- Journal of Immunology Research, Vol 2020 (2020), Journal of Immunology Research
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Atherosclerosis is a multifactorial chronic inflammatory arterial disease forming the pathological basis of many cardiovascular diseases such as coronary heart disease, heart failure, and stroke. Numerous studies have implicated inflammation as a key player in the initiation and progression of atherosclerosis. Galectin-3 (Gal-3) is a 30 kDaβ-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the process of intravascular inflammation, lipid endocytosis, macrophage activation, cellular proliferation, monocyte chemotaxis, and cell adhesion. This review focuses on the role of Gal-3 in atherosclerosis and the mechanism involved and several classical Gal-3 agonists and antagonists in the current studies.
- Subjects :
- 0301 basic medicine
Monocyte chemotaxis
Galectin 3
Galectins
Immunology
Inflammation
Review Article
030204 cardiovascular system & hematology
medicine.disease_cause
Mice
03 medical and health sciences
0302 clinical medicine
Mediator
Animals
Humans
Immunology and Allergy
Medicine
Macrophage
Endothelium
Cell adhesion
business.industry
Macrophages
Blood Proteins
General Medicine
RC581-607
Atherosclerosis
medicine.disease
Disease Models, Animal
Oxidative Stress
030104 developmental biology
Galectin-3
Heart failure
Disease Susceptibility
Immunologic diseases. Allergy
medicine.symptom
business
Biomarkers
Oxidative stress
Foam Cells
Subjects
Details
- ISSN :
- 23147156 and 23148861
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....61cdf9873c41ee015f6ebdc9a6e439ec