Synthesis of α,γ-Peptide Hybrids by Selective Conversion of Glutamic Acid Units

The site-selective modification of small peptides at a glutamate residue allows the ready preparation of α,γ-hybrids. In this way, a single peptide can be transformed into a variety of hybrid derivatives. The process takes place under very mild conditions, and good global yields are obtained.
This work was supported by the Research Program CTQ2009-07109 of the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica, Ministerio de Ciencia e Innovación/Economía y Competitividad, Spain. We also acknowledge financial support from FEDER funds. C.J.S. thanks ACIISI(Gobierno de Canarias) for a predoctoral fellowship