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The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges
- Source :
- Pharmaceutics, Pharmaceutics, Vol 12, Iss 774, p 774 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Histidines incorporated into carriers of nucleic acids may enhance the extracellular stability of the nanoparticle, yet aid in the intracellular disruption of the nanoparticle, enabling the release of the nucleic acid. Moreover, protonation of histidines in the endosomes may result in endosomal swelling with subsequent lysis. These properties of histidine are based on its five-member imidazole ring in which the two nitrogen atoms may form hydrogen bonds or act as a base in acidic environments. A wide variety of carriers have integrated histidines or histidine-rich domains, which include peptides, polyethylenimine, polysaccharides, platform delivery systems, viral phages, mesoporous silica particles, and liposomes. Histidine-rich carriers have played key roles in our understanding of the stability of nanocarriers and the escape of the nucleic acids from endosomes. These carriers show great promise and offer marked potential in delivering plasmids, siRNA, and mRNA to their intracellular targets.
- Subjects :
- Lysis
Endosome
lcsh:RS1-441
Pharmaceutical Science
02 engineering and technology
Review
imidazole
lcsh:Pharmacy and materia medica
03 medical and health sciences
chemistry.chemical_compound
Histidine
polymers
030304 developmental biology
0303 health sciences
Liposome
Polyethylenimine
Chemistry
polyplexes
histidine
021001 nanoscience & nanotechnology
gene therapy
nucleic acids
Biophysics
Nucleic acid
peptides
nanoparticles
Nanocarriers
0210 nano-technology
Intracellular
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 12
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....61c69b4a24b24a4d5067671d6cf0035d