Back to Search
Start Over
Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin
- Source :
- ACS Combinatorial Science. 15:452-457
- Publication Year :
- 2013
- Publisher :
- American Chemical Society (ACS), 2013.
-
Abstract
- Elucidating how molecules bind to HSA is fundamental for predicting drug incompatibilities. Through combinatorial screening, we identified a novel fluorescent dye (BD140) with turn-on fluorescence emission and specific binding at HSA drug site 2. We further combined it with dansylamide to develop a fluorescent dye cocktail for high-throughput mapping of the interaction between therapeutics at HSA drug-binding sites.
- Subjects :
- Models, Molecular
Drug
media_common.quotation_subject
High-throughput screening
Pharmacokinetics
medicine
Humans
Multiplex
Serum Albumin
Fluorescent Dyes
media_common
Binding Sites
Molecular Structure
Drug discovery
Chemistry
General Chemistry
General Medicine
Human serum albumin
Site mapping
Fluorescence
High-Throughput Screening Assays
body regions
Pharmaceutical Preparations
Biochemistry
embryonic structures
medicine.drug
Subjects
Details
- ISSN :
- 21568944 and 21568952
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- ACS Combinatorial Science
- Accession number :
- edsair.doi.dedup.....61add68f63e6fe6fd7e161243b5a6881