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A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation
- Source :
- Toxicology and Applied Pharmacology. 428:115648
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Acute lung injury (ALI) is a diffuse lung dysfunction disease characterized by high prevalence and high mortality. Thus far, no effective pharmacological treatment has been made for ALI in clinics. Inflammation is critical to the development of ALI. Therefore, anti-inflammation may be a potential therapy strategy for ALI. Indazole-containing derivatives, representing one of the most important heterocycles in drug molecules, are endowed with a broad range of biological properties, such as anti-cancer and anti-inflammation. In the current study, we investigated the biological effects of Cyy-272, a newly synthesized indazole compound, on LPS-induced ALI both in vivo and in vitro. Results show that Cyy-272 can inhibit the release of inflammatory cytokines in LPS-stimulated macrophage and alleviate LPS induced ALI. Further experiment revealed that Cyy-272 exhibit anti-inflammation activity by inhibiting JNK phosphorylation. Overall, our studies show that an indazole derivative, Cyy-272, is effective in suppressing LPS-induced JNK activation and inflammatory signaling.
- Subjects :
- Lipopolysaccharides
Male
Indazoles
MAP Kinase Kinase 4
Acute Lung Injury
Inflammation
Pharmacology
Lung injury
Toxicology
Proinflammatory cytokine
Mice
chemistry.chemical_compound
In vivo
medicine
Animals
Macrophage
Phosphorylation
Mice, Inbred ICR
Indazole
Dose-Response Relationship, Drug
Chemistry
respiratory system
In vitro
Protein Structure, Tertiary
respiratory tract diseases
Mice, Inbred C57BL
RAW 264.7 Cells
medicine.symptom
Subjects
Details
- ISSN :
- 0041008X
- Volume :
- 428
- Database :
- OpenAIRE
- Journal :
- Toxicology and Applied Pharmacology
- Accession number :
- edsair.doi.dedup.....6191f2f6b4898014c01371b87d5ce01a