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A fatal case of pontine hemorrhage related to methamphetamine abuse
- Source :
- Journal of forensic and legal medicine. 14(7)
- Publication Year :
- 2006
-
Abstract
- In this report, we describe a fatal case of pontine hemorrhage related with methamphetamine abuse. A 54-year-old male was found dead in a prone position in his parents’ house, and a medico-legal autopsy was carried out to determine the cause of his death. Externally, although an injection mark-like injury with subcutaneous hemorrhage was observed in the left cubital fossa, the autopsy revealed no severe trauma leading to death. Internally, every organ was moderately congested. The brain weighed 1330 g. Macroscopically, there was no vascular abnormality such as aneurysm or malformation. In the sections of the brain stem, a massive hematoma occupied the central area of the pons. Drug screening test using Triage™ was weakly positive for amphetamines. Moreover, in the blood and urine samples, methamphetamine was quantitatively detected at concentrations of 0.4 and 0.6 mg/l, respectively, by gas chromatography–mass spectrometry. Other drugs and poison were not detected in the blood and urine samples collected at autopsy. Histopathologically, necrotizing angiitis characterized by fibrinoid necrosis of the intima and media was observed with cell infiltration. Thus, the pontine hemorrhage seemingly resulted from methamphetamine-induced angiitis, with an acute elevation of blood pressure after methamphetamine abuse.
- Subjects :
- Male
Forensic pathology
Pathology
medicine.medical_specialty
Amphetamine-Related Disorders
Autopsy
Pathology and Forensic Medicine
Methamphetamine
Hematoma
Aneurysm
Pons
medicine
Humans
Fibrinoid necrosis
Forensic Pathology
Intracerebral hemorrhage
business.industry
General Medicine
Middle Aged
medicine.disease
Anesthesia
Subcutaneous hemorrhage
Central Nervous System Stimulants
business
Law
Intracranial Hemorrhages
medicine.drug
Subjects
Details
- ISSN :
- 1752928X
- Volume :
- 14
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of forensic and legal medicine
- Accession number :
- edsair.doi.dedup.....618599157d9fd49f5b111bf401e8bf9d