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Treatment of depression in Parkinson's disease
- Source :
- Parkinsonism & Related Disorders. 10:S37-S41
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Depression is an important and common nonmotor feature of Parkinson's disease (PD) that is associated with significant disability and a negative impact on quality of life. The physician should remain vigilant for symptoms of depression as they may be mistaken for the progression of Parkinson's disease itself. Transient dysphoria that occurs during 'off' periods in fluctuating PD patients must be distinguished from true depression. Antidepressant therapy should be instituted if depression is interfering with the patient's daily function. The use of serotonin reuptake inhibitors and tricyclic antidepressants in the treatment of depression in PD is widespread in clinical practice. Dopamine agonists may be effective in the treatment of milder depression as well. Individual or family counseling may be helpful. In patients with severe depression who are refractory to antidepressant medications, a series of electroconvulsive treatments can be lifesaving. Nonconventional therapies such as transcranial magnetic stimulation are being investigated.
- Subjects :
- medicine.medical_specialty
Pediatrics
Parkinson's disease
Disease
Dysphoria
Quality of life (healthcare)
Dopamine
medicine
Animals
Humans
Psychiatry
Depression (differential diagnoses)
chemistry.chemical_classification
Depression
Parkinson Disease
medicine.disease
Antidepressive Agents
Neurology
chemistry
Antidepressant
Neurology (clinical)
Geriatrics and Gerontology
medicine.symptom
Psychology
medicine.drug
Tricyclic
Subjects
Details
- ISSN :
- 13538020
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Parkinsonism & Related Disorders
- Accession number :
- edsair.doi.dedup.....61841ae34b1ad5ff5c62eeb1d7cc31a6