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Randomized clinical trial comparing endoscopic treatment with dextranomer hyaluronic acid copolymer and Cohen's ureteral reimplantation for vesicoureteral reflux: long-term results
- Source :
- Journal of pediatric urology. 9(4)
- Publication Year :
- 2012
-
Abstract
- Purpose To compare efficacy of Cohen's ureteral reimplantation and endoscopic treatment with Dx/HA in patients with primary VUR grades II, III and IV. Methods From April 2002 to June 2004, patients over 1 year old with VUR grade I, II, III or IV were included. Patients were randomized into two groups: endoscopic treatment (ET) or ureteral reimplantation (UR). In the ET group, an ultrasonography study was performed 24 h and 1 month after surgery, and two voiding cystourethrographies at 3 and 6 months post treatment. In the UR group, an ultrasonography study was done 7 days and 1 month after surgery and a micturial cystography 6 months post surgery. A postoperative nuclear direct cystogram was performed 5 years later in both groups. Results A total of 41 patients were included in this study: in ET 22 patients with 35 refluxing ureters and in UR 19 patients with 32 refluxing ureters. The VUR grades in ET were: 16 grade II, 16 grade III and 3 grade IV; and in UR: 15 grade II, 12 grade III and 5 grade IV. VUR was resolved in 91% (32/35) of ET (28% of ureters needed a second injection), and in 100% of UR group. Five years after the procedure, VUR was still resolved in 30/32 of ET and 32/32 of UR. Conclusion Short- and long-term follow up shows that multiple endoscopic treatment of VUR grades II, III and IV with Dx/HA is as effective as ureteral reimplantation.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Urology
urologic and male genital diseases
Vesicoureteral reflux
law.invention
Cystography
Randomized controlled trial
law
Dextranomer-hyaluronic acid copolymer
medicine
Humans
Ureteral Diseases
Hyaluronic Acid
Child
Vesico-Ureteral Reflux
medicine.diagnostic_test
business.industry
Dextrans
Endoscopy
Long term results
medicine.disease
female genital diseases and pregnancy complications
Surgery
Treatment Outcome
Child, Preschool
Replantation
Pediatrics, Perinatology and Child Health
Urologic Surgical Procedures
Female
Post treatment
business
Endoscopic treatment
Ureteral reimplantation
Follow-Up Studies
Subjects
Details
- ISSN :
- 18734898
- Volume :
- 9
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of pediatric urology
- Accession number :
- edsair.doi.dedup.....61784eb1e3361c9da43a06b6b32dbec6