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Risk-reduction surgery in BRCA mutation carriers in a Spanish population: adherence and results
- Source :
- Clinical and Translational Oncology. 10:660-664
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- To analyse the level of adherence to prophylactic surgery of breast and/or ovarian cancer in female carriers of the BRCA1 or BRCA2 mutation in a referential genetic counselling unit in Spain. Between January 1998 and November 2006, a total of 684 families with several cases of breast and/or ovarian cancer were selected by the Genetic Counselling Unit at the Hospital Clinico Universitario San Carlos. Some of them opted for prophylactic surgery after genetic counselling and genetic testing. The pathogenic mutation was found in 57 families out of a total of 449 families who fulfilled the hereditary breast/ovarian cancer criteria. Out of a total of 238 individuals who were carriers of the mutation, 136 (57%) were offered risk-reducing prophylactic surgery. Prophylactic surgery was chosen by 58 (43%) women out of a total of 136 who were offered this possibility; the histological findings observed 7% malignant lesions in the breast and, in the ovarian-fallopian complex, 2 cases (8%) of a borderline tumour and one case (4%) of papillary adenocarcinoma. This is the first study published on the role of prophylactic surgery in BRCA mutation carriers in the Spanish population. The incidence of occult carcinoma in these cases is lower than in other series.
- Subjects :
- Adult
Heterozygote
Cancer Research
medicine.medical_specialty
Genetic counseling
Genes, BRCA2
Population
Genes, BRCA1
Breast Neoplasms
Genetic Counseling
Papillary adenocarcinoma
medicine
Humans
Family
education
Genetic testing
Ovarian Neoplasms
education.field_of_study
medicine.diagnostic_test
business.industry
Incidence (epidemiology)
Carcinoma
BRCA mutation
General Medicine
medicine.disease
Prophylactic Surgery
Surgery
Oncology
Spain
Mutation
Patient Compliance
Female
Preventive Medicine
business
Ovarian cancer
Subjects
Details
- ISSN :
- 16993055 and 1699048X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Oncology
- Accession number :
- edsair.doi.dedup.....6168a14934a69255e611eed355a5799d