Back to Search
Start Over
The Woronoff Ring in Psoriasis and the Mechanisms of Postinflammatory Hypopigmentation
- Source :
- Acta Dermato-Venereologica, Vol 100, Iss 3, p adv00031 (2020)
- Publication Year :
- 2020
-
Abstract
- The Woronoff ring is a ring-like hypopigmentation zone around regressing psoriasis lesions. Although it was first described more than 100 years ago, its aetiology has remained a mystery. Recent insights into the pathogenesis of psoriasis can now explain the origin of the Woronoff ring. Psoriasis involves an HLA-class I-restricted autoimmune response of CD8+ T cells against melanocytes in the epidermis. The pathogenic CD8+ T cells are not cytotoxic, but are characterized by the production of interleukin-17, interleukin-22 and tumour necrosis factor-α. Interleukin-17 and tumour necrosis factor-α act synergistically on melanocytes by increasing proliferation while inhibiting melanogenesis. This reduces the cellular melanin content despite an increased number of melanocytes in psoriatic lesions. As a consequence, during healing the prior influence of interleukin-17 and tumour necrosis factor-α, despite the increased density of melanocytes, leaves a hypopigmented zone at the edge of regressing psoriasis lesions, which becomes visible as the Woronoff ring. This mechanism can explain a long-discussed puzzling phenomenon in dermatology.
- Subjects :
- Necrosis
Dermatology
CD8-Positive T-Lymphocytes
Melanin
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Psoriasis
medicine
lcsh:Dermatology
Cytotoxic T cell
Humans
Hypopigmentation
Aged
Cell Proliferation
Melanins
Epidermis (botany)
business.industry
Tumor Necrosis Factor-alpha
Interleukin-17
General Medicine
lcsh:RL1-803
medicine.disease
030220 oncology & carcinogenesis
Cancer research
woronoff ring
Melanocytes
Female
medicine.symptom
business
Postinflammatory hypopigmentation
CD8
Subjects
Details
- ISSN :
- 16512057
- Volume :
- 100
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Acta dermato-venereologica
- Accession number :
- edsair.doi.dedup.....615bf68798edcab522ba4b003511baf4