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Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: A retrospective cohort study at a major sarcoma center
- Source :
- J Surg Oncol
- Publication Year :
- 2017
-
Abstract
- Background We investigated whether concomitant organ removal as part of the primary resection of RP WDLPS confers an outcome advantage in patients treated at a major sarcoma center. Methods The departmental sarcoma database was reviewed to identify patients with RP WDLPS who underwent initial surgical resection for primary disease at MD Anderson Cancer Center during the study period 1995-2011. We retrospectively reviewed medical records and examined associations between clinicopathologic variables and overall survival (OS) as well as disease-free survival (DFS). Results Among 83 patients included in this study, 76 patients (92%) underwent complete resection (R0/R1). Concomitant organ resections were performed in 38 patients (46%). Invasion of the resected organ/s was seen in six patients (7%). Estimated OS was 11.3 years (5-year OS, 86%), and DFS was 5.4 years (5-year DFS, 51%). By multivariate analysis, concomitant organ resection was not associated with improved OS (P = 0.428) or DFS (P = 0.946), and lack of organ resection was associated with a lower risk of postoperative complications (P = 0.01). Conclusions Concomitant organ resection was not associated with a survival benefit in RP WDLPS in this study. In patients with primary RP WDLPS, we recommend selective resection of contiguous organs only if there is clinical suspicion of invasion.
- Subjects :
- Male
medicine.medical_specialty
Databases, Factual
Lower risk
Article
Resection
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
medicine
Humans
Retroperitoneal Space
Retrospective Studies
Well Differentiated Liposarcoma
business.industry
Medical record
Cancer
Retrospective cohort study
General Medicine
Liposarcoma
Middle Aged
medicine.disease
Prognosis
Surgery
Survival Rate
Oncology
030220 oncology & carcinogenesis
Concomitant
030211 gastroenterology & hepatology
Female
Sarcoma
Neoplasm Recurrence, Local
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 10969098
- Volume :
- 117
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of surgical oncology
- Accession number :
- edsair.doi.dedup.....61450871b7915ec31486710627ab055b