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Characterization of Ross River Virus Tropism and Virus-Induced Inflammation in a Mouse Model of Viral Arthritis and Myositis
- Publication Year :
- 2006
- Publisher :
- American Society for Microbiology, 2006.
-
Abstract
- Mosquito-borne alphaviruses are a significant cause of both encephalitic and arthritic disease in humans worldwide. In contrast to the encephalitic alphaviruses, the pathogenesis of alphavirus-induced arthritic disease is not well understood. Utilizing a mouse model of Ross River virus (RRV) disease, we found that the primary targets of RRV infection are bone, joint, and skeletal muscle tissues of the hind limbs in both outbred CD-1 mice and adult C57BL/6J mice. Moreover, histological analyses demonstrated that RRV infection resulted in severe inflammation of these tissues. Characterization of the inflammatory infiltrate within the skeletal muscle tissue identified inflammatory macrophages, NK cells, and CD4+and CD8+T lymphocytes. To determine the contribution of the adaptive immune system, the outcome of RRV-induced disease was examined in C57BL/6J RAG-1−/−mice, which lack functional T and B lymphocytes. RAG-1−/−and wild-type mice developed similar disease signs, infiltration of inflammatory macrophages and NK cells, and muscle pathology, suggesting that the adaptive immune response does not play a critical role in the development of disease. These results establish the mouse model of RRV disease as a useful system for the identification of viral and host factors that contribute to alphavirus-induced arthritis and myositis.
- Subjects :
- CD4-Positive T-Lymphocytes
viruses
Immunology
Arthritis
Inflammation
Alphavirus
CD8-Positive T-Lymphocytes
Microbiology
Virus
Bone and Bones
Pathogenesis
Mice
Viral arthritis
Virology
medicine
Ross River virus
Animals
Muscle, Skeletal
Myositis
Homeodomain Proteins
Mice, Knockout
Arthritis, Infectious
biology
Alphavirus Infections
Macrophages
virus diseases
biology.organism_classification
medicine.disease
Acquired immune system
Hindlimb
Killer Cells, Natural
Mice, Inbred C57BL
Disease Models, Animal
Organ Specificity
Insect Science
Pathogenesis and Immunity
Female
Joints
medicine.symptom
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6143b586886ce14a18a45add3a4dcfa0