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Triptorelin depot for the treatment of children 2 years and older with central precocious puberty
- Publication Year :
- 2018
-
Abstract
- Triptorelin depot is largely used to treat central precocious puberty (CPP) in children. Areas covered: This review updates triptorelin depot treatment of CPP, focusing on trials that compared 3.75 mg/28 day treated and untreated children till the adult height (AH). Efficacy of the new 11.25 mg/90 days or 22.5 mg/6 month formulations in suppressing pituitary-gonadal axis in short-term trials is also addressed. Short- and long-term safety was summarized. Expert commentary: Long experience on triptorelin depot use in children with CPP is available. Outcome differences on AH are reported; they may be due to heterogenicity of treated patients; some items remain to be optimized. No long term-adverse events on reproductive function are reported; additional studies would clarify if CPP per sè or triptorelin depot administration may increase hyperandrogenism and/or polycystic ovary syndrome risk in adulthood. The quarterly formulation seems to be able to suppress pituitary-gonadal axis and pubertal development and to determine similar end-results as monthly formulation, but additional trials are needed. Few data are available for the 22.5 mg/6 month formulation. Triptorelin depot treatment of CPP should be restricted to tertiary pediatric endocrinology centers, considering that some uncertainties still exist and that rare but serious adverse events may occur.
- Subjects :
- Pediatrics
medicine.medical_specialty
Time Factors
Depot
Central precocious puberty
Puberty, Precocious
030209 endocrinology & metabolism
Drug Administration Schedule
Gonadotropin-Releasing Hormone
03 medical and health sciences
0302 clinical medicine
Triptorelin 3.75 MG
030225 pediatrics
polycyclic compounds
Medicine
Humans
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Child
Triptorelin Pamoate
business.industry
nutritional and metabolic diseases
GnRH Analog
General Medicine
Triptorelin
Adult height
body regions
Treatment Outcome
Child, Preschool
Delayed-Action Preparations
business
hormones, hormone substitutes, and hormone antagonists
psychological phenomena and processes
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....613da499d2e225ec7c5af64f9abdfe5a