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Urinaryp-cresol is elevated in young French children with autism spectrum disorder: a replication study
- Source :
- Biomarkers. 19:463-470
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex- and age-matched controls (p
- Subjects :
- Pervasive developmental disorders
Male
Pathology
Health, Toxicology and Mutagenesis
Clinical Biochemistry
Biochemistry
Clinical biochemistry
Cresols
organic contaminants
neurotoxicity
Gut flora
pervasive developmental disorders
p-cresylsulfate
Urinary levels
Child
Settore BIO/12
P-cresylsulfate
Settore MED/39 - Neuropsichiatria Infantile
Gut flora, neurotoxicity, organic contaminants, p-cresylsulfate, pervasive developmental disorders
Health
Autism spectrum disorder
Child, Preschool
Biomarker (medicine)
Female
France
medicine.medical_specialty
Child Development Disorders
Adolescent
Urinary system
Glucuronates
Sulfuric Acid Esters
Organic contaminants
Neurotoxicity
Case-Control Studies
Pervasive
Preschool
Humans
Toxicology and Mutagenesis
Internal medicine
parasitic diseases
medicine
Settore BIO/10 - BIOCHIMICA
business.industry
Case-control study
medicine.disease
Child Development Disorders, Pervasive
Autism
business
Subjects
Details
- ISSN :
- 13665804 and 1354750X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Biomarkers
- Accession number :
- edsair.doi.dedup.....613814e641b16353fd84e6ab9173cfc7