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Maresin1 ameliorates sepsis-associated lung injury by inhibiting the activation of the JAK2/STAT3 and MAPK/ NF-κB signaling pathways
- Source :
- Microbial pathogenesis. 148
- Publication Year :
- 2020
-
Abstract
- Sepsis-associated acute lung injury (ALI) is a clinically critical disease that carries a high mortality rate. The pathogenesis of sepsis-associated ALI has not yet been precisely elucidated and there is a lack of effective treatment. As a new endogenous docosahexaenoic acid (DHA)-derived lipid mediators, Maresin1 has a significant dual role of anti-inflammatory and promoting inflammation regression. In this study, we established the sepsis model by the cecal ligation and puncture method (CLP) to explore the effect of Maresin1 on sepsis-induced lung injury. We found that the intervention of Maresin1 could significantly attenuate the sepsis-induced inflammatory responses, characterized by the down-regulation of the level of IL-1β, IL-6, TNF-α, MPO, etc. Maresin1 could also significantly decrease the number of neutrophils in lung tissue, thus improving the related lung injury indicators. Our experiment clarified that the protective effect of Maresin1 on sepsis-associated lung injury is closely related to its inhibition function of JAK2/STAT3 and MAPK/NF-κB signaling pathways. Our findings provide new research directions and therapeutic targets for sepsis-associated ALI.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
STAT3 Transcription Factor
MAP Kinase Signaling System
030106 microbiology
Acute Lung Injury
Inflammation
Pharmacology
Lung injury
Microbiology
Pathogenesis
Sepsis
03 medical and health sciences
chemistry.chemical_compound
Medicine
Humans
STAT3
Lung
biology
business.industry
Tumor Necrosis Factor-alpha
NF-kappa B
NF-κB
Lipid signaling
respiratory system
Janus Kinase 2
medicine.disease
respiratory tract diseases
030104 developmental biology
Infectious Diseases
chemistry
biology.protein
medicine.symptom
business
Subjects
Details
- ISSN :
- 10961208
- Volume :
- 148
- Database :
- OpenAIRE
- Journal :
- Microbial pathogenesis
- Accession number :
- edsair.doi.dedup.....61371641add1d0ff4261b47bdeb03b92