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Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells
- Source :
- Redox Biology, Vol 19, Iss, Pp 158-165 (2018), Redox Biology
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Tumorigenesis is commonly known as a complicated process, in which reactive oxygen species (ROS) plays a critical role to involve in signal transduction, metabolism, cell proliferation and differentiation. Previously, ribosomal protein L10 (RPL10) was suggested to possess extra-ribosomal functions in pancreatic cancer cells in addition to being proposed as a tumor suppressor or transcription co-regulator. To better understand the relationship between RPL10 and tumorigenic potential in pancreatic cancer cells, chromatin immunoprecipitation sequencing reveals that RPL10 is unlikely to be a transcription factor without a specific binding motif for gene transcription. Additionally, transcriptome analysis indicates that RPL10 could regulate the expression of proteins related to ROS production. Moreover, RPL10 in mitochondria is closely associated with the regulation of ROS level by affecting Complex I activity and the subsequent events. Together, the present study suggests that the regulation of ROS level by mitochondrial RPL10 is one of the major extra-ribosomal functions in pancreatic cancer cells, which could be used as an indicator for the tumorigenesis of pancreatic cancer.<br />Graphical abstract fx1<br />Highlights • RPL10 exists in mitochondria. • RPL10 affects the expression of proteins related to oxidative stress and ROS generation. • RPL10 regulates ROS level in pancreatic cancer cells.
- Subjects :
- Ribosomal Proteins
0301 basic medicine
Ribosomal Protein L10
Carcinogenesis
Clinical Biochemistry
Mitochondrion
Biology
medicine.disease_cause
Biochemistry
Transcriptome
03 medical and health sciences
0302 clinical medicine
RPL10
Ribosomal protein
Transcription (biology)
Cell Line, Tumor
Pancreatic cancer
medicine
Humans
Transcription factor
lcsh:QH301-705.5
lcsh:R5-920
Organic Chemistry
ROS
medicine.disease
Mitochondria
Cell biology
Gene Expression Regulation, Neoplastic
Pancreatic Neoplasms
030104 developmental biology
lcsh:Biology (General)
030220 oncology & carcinogenesis
Signal transduction
Reactive Oxygen Species
lcsh:Medicine (General)
Research Paper
Regulation
Subjects
Details
- Language :
- English
- ISSN :
- 22132317
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Redox Biology
- Accession number :
- edsair.doi.dedup.....61324f26bac831f1953f36d8a50e2701