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Differences in pO2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation
- Source :
- Journal of Radiation Research. 45:303-308
- Publication Year :
- 2004
- Publisher :
- Oxford University Press (OUP), 2004.
-
Abstract
- We measured and compared the oxygen partial pressure (pO2) profiles in experimental tumors after irradiation with carbon ions and with X-rays. The NFSa fibrosarcomas grown in the hind legs of C3H male mice received isoeffect single doses of carbon ions or X-rays. Coaxial oxygen microelectrodes of high spatial resolution were inserted into the tumor with 20 micrometer steps by a computerized micromanipulator. The number of pO2 peaks that reached 15 mmHg were at least 0.45 per 3,000 micrometer in unirradiated tumors and significantly increased to 1.55 per 3,000 micrometer as early as day 1 of carbon-ion irradiation (p
- Subjects :
- Male
Fibrosarcoma
Health, Toxicology and Mutagenesis
Linear energy transfer
chemistry.chemical_element
Murine fibrosarcoma
Oxygen
Ion
Mice
Oxygen Consumption
medicine
Relative biological effectiveness
Animals
Heavy Ions
Linear Energy Transfer
Radiology, Nuclear Medicine and imaging
Irradiation
Mice, Inbred C3H
Radiation
business.industry
X-Rays
Radiochemistry
Partial pressure
medicine.disease
Carbon
Cell Hypoxia
Treatment Outcome
chemistry
Nuclear medicine
business
Relative Biological Effectiveness
Subjects
Details
- ISSN :
- 04493060
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Journal of Radiation Research
- Accession number :
- edsair.doi.dedup.....612d3f44750f06eaabc8de3159808691
- Full Text :
- https://doi.org/10.1269/jrr.45.303