Back to Search Start Over

Differences in pO2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation

Authors :
Kazuo Tanishita
Koichi Ando
Kotaro Oka
Hirosuke Kobayashi
Sachiko Koike
Koji Takematsu
Takeshi Fukawa
Source :
Journal of Radiation Research. 45:303-308
Publication Year :
2004
Publisher :
Oxford University Press (OUP), 2004.

Abstract

We measured and compared the oxygen partial pressure (pO2) profiles in experimental tumors after irradiation with carbon ions and with X-rays. The NFSa fibrosarcomas grown in the hind legs of C3H male mice received isoeffect single doses of carbon ions or X-rays. Coaxial oxygen microelectrodes of high spatial resolution were inserted into the tumor with 20 micrometer steps by a computerized micromanipulator. The number of pO2 peaks that reached 15 mmHg were at least 0.45 per 3,000 micrometer in unirradiated tumors and significantly increased to 1.55 per 3,000 micrometer as early as day 1 of carbon-ion irradiation (p

Details

ISSN :
04493060
Volume :
45
Database :
OpenAIRE
Journal :
Journal of Radiation Research
Accession number :
edsair.doi.dedup.....612d3f44750f06eaabc8de3159808691
Full Text :
https://doi.org/10.1269/jrr.45.303