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Effects of Ulva sp. Extracts on the Growth, Biofilm Production, and Virulence of Skin Bacteria Microbiota: Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes Strains
- Source :
- Molecules, Molecules, Vol 26, Iss 4763, p 4763 (2021), Volume 26, Issue 16
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Ulva sp. is known to be a source of bioactive compounds such as ulvans, but to date, their biological activity on skin commensal and/or opportunistic pathogen bacteria has not been re­ported. In this study, the effects of poly- and oligosaccharide fractions produced by enzyme-assisted extraction and depolymerization were investigated, for the first time in vitro, on cutaneous bacteria: Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes. At 1000 μg/mL, poly- and oligosaccharide fractions did not affect the growth of the bacteria regarding their generation time. Polysaccharide Ulva sp. fractions at 1000 μg/mL did not alter the bacterial biofilm formation, while oligosaccharide fractions modified S. epidermidis and C. acnes biofilm structures. None of the fractions at 1000 μg/mL significantly modified the cytotoxic potential of S. epidermidis and S. aureus towards keratinocytes. However, poly- and oligosaccharide fractions at 1000 μg/mL induced a decrease in the inflammatory potential of both acneic and non-acneic C. acnes strains on keratinocytes of up to 39.8%<br />the strongest and most significant effect occurred when the bacteria were grown in the presence of polysaccharide fractions. Our research shows that poly- and oligosaccharide Ulva sp. fractions present notable biological activities on cutaneous bacteria, especially towards C. acnes acneic and non-acneic strains, which supports their potential use for dermo-cosmetic applications.
- Subjects :
- Staphylococcus aureus
Pharmaceutical Science
Virulence
medicine.disease_cause
Polysaccharide
Article
biofilm
Analytical Chemistry
Microbiology
Ulva
QD241-441
ulvan
Staphylococcus epidermidis
Drug Discovery
Cutibacterium acnes
medicine
Physical and Theoretical Chemistry
Skin
chemistry.chemical_classification
biology
Bacteria
Dose-Response Relationship, Drug
EAE
Plant Extracts
Microbiota
Organic Chemistry
Biofilm
Biological activity
Oligosaccharide
Propionibacteriaceae
biology.organism_classification
chemistry
Chemistry (miscellaneous)
inflammation
seaweed
Molecular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....611d4c47a34b08fabefa9d8ff580a3c0