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Regulation of Cued Fear Expression via Corticotropin-Releasing-Factor Neurons in the Ventral Anteromedial Thalamic Nucleus
- Source :
- Neurosci Bull
- Publication Year :
- 2020
- Publisher :
- Springer Singapore, 2020.
-
Abstract
- The ventral part of the anteromedial thalamic nucleus (AMv) is in a position to convey information to the cortico-hippocampal-amygdalar circuit involved in the processing of fear memory. Corticotropin-releasing-factor (CRF) neurons are closely associated with the regulation of stress and fear. However, few studies have focused on the role of thalamic CRF neurons in fear memory. In the present study, using a conditioned fear paradigm in CRF transgenic mice, we found that the c-Fos protein in the AMv CRF neurons was significantly increased after cued fear expression. Chemogenetic activation of AMv CRF neurons enhanced cued fear expression, whereas inhibition had the opposite effect on the cued fear response. Moreover, chemogenetic manipulation of AMv CRF neurons did not affect fear acquisition or contextual fear expression. In addition, anterograde tracing of projections revealed that AMv CRF neurons project to wide areas of the cerebral cortex and the limbic system. These results uncover a critical role of AMv CRF neurons in the regulation of conditioned fear memory. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12264-020-00592-6) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
Genetically modified mouse
endocrine system
animal structures
Physiology
Corticotropin-Releasing Hormone
Biology
03 medical and health sciences
Mice
0302 clinical medicine
Limbic system
Adrenocorticotropic Hormone
medicine
Animals
Cued speech
Neurons
Anteromedial Nucleus
General Neuroscience
General Medicine
Chemogenetics
Fear
Anterograde tracing
030104 developmental biology
medicine.anatomical_structure
nervous system
Anterior Thalamic Nuclei
Cerebral cortex
embryonic structures
Original Article
Ventral part
Neuroscience
030217 neurology & neurosurgery
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Neurosci Bull
- Accession number :
- edsair.doi.dedup.....610b49dc7b9b53f3115d0c06513d0c1c