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Xath2, a bHLH gene expressed during a late transition stage of neurogenesis in the forebrain of Xenopus embryos
- Source :
- Mechanisms of Development. 101:199-202
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- We have identified a Xenopus bHLH gene, Xath2, which is the homologue of the murine MATH-2/NEX-1 gene, using a functional expression screening approach. Overexpression of this gene in neurula embryos induces the expression of the N-tubulin neuronal marker but does not stimulate the expression of the X-ngnr-1 and NeuroD proneural genes. Expression of Xath2 begins in stage 32 embryos and is restricted to the dorsal telencephalon. Within the neuroepithelium of the dorsal telencephalon, Xath2 expression is detected in postmitotic cells located more laterally than those expressing several other related bHLH neuronal regulators.
- Subjects :
- Embryology
DNA, Complementary
Embryo, Nonmammalian
Time Factors
animal structures
Xenopus
Molecular Sequence Data
Nerve Tissue Proteins
Proneural genes
Xenopus Proteins
Biology
Mice
Prosencephalon
Tubulin
Basic Helix-Loop-Helix Transcription Factors
Animals
Tissue Distribution
Amino Acid Sequence
Cloning, Molecular
Gene
In Situ Hybridization
Gene Library
Neurons
NeuroD
Sequence Homology, Amino Acid
Neurogenesis
biology.organism_classification
Molecular biology
Neuroepithelial cell
Bromodeoxyuridine
nervous system
Neurula
embryonic structures
Forebrain
Transcription Factors
Developmental Biology
Subjects
Details
- ISSN :
- 09254773
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- Mechanisms of Development
- Accession number :
- edsair.doi.dedup.....60fc6eab5291f5f39ad52f111c0d3650