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Is Sporothrix chilensis circulating outside Chile?

Authors :
Rosely Maria Zancopé-Oliveira
Rejane Pereira Neves
Ertênia Paiva Oliveira
Vanessa Brito de Souza Rabello
Reginaldo Gonçalves de Lima-Neto
Carlos Alberto Tiburcio Valeriano
Cícero Pinheiro Inácio
Rodrigo Almeida-Paes
Manoel Marques Evangelista Oliveira
Source :
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008151 (2020), PLoS Neglected Tropical Diseases
Publication Year :
2020
Publisher :
Public Library of Science (PLoS), 2020.

Abstract

Sporothrix chilensis is a mild-pathogenical specie of Sporothrix pallida complex, until now, known as restrict to Chile. Herein, we describe the first clinical isolates identified as S. chilensis in Brazil, preserved in the URM Culture Collection, by polyphasic taxonomy, and their respective antifungal profile of this emergent fungus.<br />Author summary Fungi of the Sporothrix schenckii Complex are the causative agents of the sporotrichosis, subcutaneous mycosis that presents a massive global distribution. In this work, we perform a taxonomic review, by a poliphasic approach, of Sporothrix sp. isolates stored in the University of Recife Culture Collection (Micoteca URM), previously identified as Sporothrix schenckii by classic methods of taxonomic identification. In addition, we perform the method of broth microdilution, aiming to acquire the minimal inhibitory concentration of the standard antifungals (itraconazole and amphotericin B) against these isolates. By sequencing of the partial β-tub-encoding gene, we confirm the occurrence of S. schenckii, and identified four isolates as the S. pallida Complex component, S. chilensis. All the isolates were susceptible to the antifungals, except one, that shows resistance to amphotericin B. Our study demonstrated the first occurrence of S. chilensis in Brazil. Also, we provide the first data concerned the resistance profile of this specie for the choice antifungals in the sporotrichosis treatment, what will have important implications with this regard in the future.

Details

Language :
English
ISSN :
19352735 and 19352727
Volume :
14
Issue :
3
Database :
OpenAIRE
Journal :
PLoS Neglected Tropical Diseases
Accession number :
edsair.doi.dedup.....60de20666f6cf6f231d03366a7cfb802