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Is Sporothrix chilensis circulating outside Chile?
- Source :
- PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008151 (2020), PLoS Neglected Tropical Diseases
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Sporothrix chilensis is a mild-pathogenical specie of Sporothrix pallida complex, until now, known as restrict to Chile. Herein, we describe the first clinical isolates identified as S. chilensis in Brazil, preserved in the URM Culture Collection, by polyphasic taxonomy, and their respective antifungal profile of this emergent fungus.<br />Author summary Fungi of the Sporothrix schenckii Complex are the causative agents of the sporotrichosis, subcutaneous mycosis that presents a massive global distribution. In this work, we perform a taxonomic review, by a poliphasic approach, of Sporothrix sp. isolates stored in the University of Recife Culture Collection (Micoteca URM), previously identified as Sporothrix schenckii by classic methods of taxonomic identification. In addition, we perform the method of broth microdilution, aiming to acquire the minimal inhibitory concentration of the standard antifungals (itraconazole and amphotericin B) against these isolates. By sequencing of the partial β-tub-encoding gene, we confirm the occurrence of S. schenckii, and identified four isolates as the S. pallida Complex component, S. chilensis. All the isolates were susceptible to the antifungals, except one, that shows resistance to amphotericin B. Our study demonstrated the first occurrence of S. chilensis in Brazil. Also, we provide the first data concerned the resistance profile of this specie for the choice antifungals in the sporotrichosis treatment, what will have important implications with this regard in the future.
- Subjects :
- 0301 basic medicine
Antifungal Agents
RC955-962
Pathology and Laboratory Medicine
Geographical locations
0302 clinical medicine
Tubulin
Sporothrix Schenckii
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Sporothrix schenckii
Mycological Typing Techniques
Amphotericin
skin and connective tissue diseases
Data Management
Fungal Pathogens
biology
Antimicrobials
Fungal Diseases
Drugs
Eukaryota
Phylogenetic Analysis
Phylogenetics
Infectious Diseases
Medical Microbiology
Taxonomy (biology)
Pathogens
Public aspects of medicine
RA1-1270
Brazil
Research Article
Antifungal
Computer and Information Sciences
medicine.drug_class
030231 tropical medicine
Microbial Sensitivity Tests
Mycology
Fungus
Microbiology
Sporothrix pallida
03 medical and health sciences
Microbial Control
parasitic diseases
medicine
Humans
Evolutionary Systematics
Microbial Pathogens
Taxonomy
Pharmacology
Antifungals
Evolutionary Biology
Sporothrix chilensis
Sporotrichosis
Sporothrix
Organisms
Fungi
Public Health, Environmental and Occupational Health
Biology and Life Sciences
Sequence Analysis, DNA
South America
biology.organism_classification
medicine.disease
bacterial infections and mycoses
030104 developmental biology
People and places
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 14
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....60de20666f6cf6f231d03366a7cfb802