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Prediction of treatment response to adalimumab: a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis
- Source :
- Krintel, S B, Dehlendorff, C, Hetland, M L, Hørslev-Petersen, K, Andersen, K K, Junker, P, Pødenphant, J, Ellingsen, T, Ahlquist, P, Lindegaard, H M, Linauskas, A, Schlemmer, A, Dam, M Y, Hansen, I, Horn, H C, Jørgensen, A, Raun, J, Ammitzbøll, C G, Østergaard, M, Stengaard-Pedersen, K & Johansen, J S 2016, ' Prediction of treatment response to adalimumab : a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis ', Pharmacogenomics Journal, vol. 16, no. 2, pp. 141-146 . https://doi.org/10.1038/tpj.2015.30, Krintel, S B, Dehlendorff, C, Hetland, M L, Hørslev-Petersen, K, Andersen, K K, Junker, P, Pødenphant, J, Ellingsen, T, Ahlquist, P, Lindegaard, H M, Linauskas, A, Schlemmer, A, Dam, MY, Hansen, I, Horn, H C, Jørgensen, A, Raun, J, Ammitzbøll, C G, Østergaard, M, Stengaard-Pedersen, K & Johansen, J S 2016, ' Prediction of treatment response to adalimumab : a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis ', Pharmacogenomics Journal, vol. 16, no. 2, pp. 141-6 . https://doi.org/10.1038/tpj.2015.30, Krintel, S B, Dehlendorff, C, Hetland, M L, Hørslev-Petersen, K, Andersen, K K, Junker, P, Pødenphant, J, Ellingsen, T, Ahlquist, P, Lindegaard, H M, Linauskas, A, Schlemmer, A, Dam, M Y, Hansen, I, Horn, H C, Jørgensen, A, Raun, J, Ammitzbøll, C G, Østergaard, M, Stengaard-Pedersen, K & Johansen, J S 2016, ' Prediction of treatment response to adalimumab : a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis ', The Pharmacogenomics Journal, vol. 16, no. 2, pp. 141–146 . https://doi.org/10.1038/tpj.2015.30
- Publication Year :
- 2014
-
Abstract
- At least 30% of patients with rheumatoid arthritis (RA) do not respond to biologic agents, which emphasizes the need of predictive biomarkers. We aimed to identify microRNAs (miRNAs) predictive of response to adalimumab in 180 treatment-naïve RA patients enrolled in the OPtimized treatment algorithm for patients with early RA (OPERA) Study, an investigator-initiated, prospective, double-blind placebo-controlled study. Patients were randomized to adalimumab 40 mg (n=89) or placebo-adalimumab (n=91) subcutaneously in combination with methotrexate. Expressions of 377 miRNAs were determined using TaqMan Human MicroRNA LDA, A Card v2.0 (Applied Biosystems). Associations between miRNAs and treatment response were tested using interaction analyses. MiRNAs with a P-value
- Subjects :
- musculoskeletal diseases
0301 basic medicine
Male
Treatment response
medicine.medical_specialty
Placebo-controlled study
Arthritis
Antirheumatic Agents/therapeutic use
law.invention
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Double-Blind Method
Adalimumab/therapeutic use
law
Internal medicine
Genetics
medicine
Adalimumab
Humans
In patient
Prospective Studies
skin and connective tissue diseases
Prospective cohort study
030203 arthritis & rheumatology
Pharmacology
Tumor Necrosis Factor-alpha/antagonists & inhibitors
business.industry
Tumor Necrosis Factor-alpha
MicroRNAs/blood
Middle Aged
medicine.disease
humanities
Circulating MicroRNA
MicroRNAs
030104 developmental biology
Arthritis, Rheumatoid/drug therapy
Antirheumatic Agents
Immunology
Molecular Medicine
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14731150
- Volume :
- 16
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The pharmacogenomics journal
- Accession number :
- edsair.doi.dedup.....60db69177199293d3152077ddf142c70
- Full Text :
- https://doi.org/10.1038/tpj.2015.30