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Cys(577) is a conformationally mobile residue in the ATP-binding domain of the Na,K-ATPase alpha-subunit
- Source :
- The Journal of biological chemistry. 274(35)
- Publication Year :
- 1999
-
Abstract
- 2-[4'-Maleimidylanilino]naphthalene 6-sulfonic acid (MIANS) irreversibly inactivates Na,K-ATPase in a time- and concentration-dependent manner. Inactivation is prevented by 3 mM ATP or low K(+) (
- Subjects :
- Cation binding
Stereochemistry
Peptide
Biochemistry
Anilino Naphthalenesulfonates
Adenosine Triphosphate
ATP hydrolysis
Cations
Trypsin
Cysteine
Binding site
Na+/K+-ATPase
Enzyme Inhibitors
Molecular Biology
Chromatography, High Pressure Liquid
Gel electrophoresis
chemistry.chemical_classification
Binding Sites
Cell Biology
Peptide Fragments
Amino acid
Kinetics
chemistry
Electrophoresis, Polyacrylamide Gel
Sodium-Potassium-Exchanging ATPase
Sequence Analysis
Binding domain
Protein Binding
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 274
- Issue :
- 35
- Database :
- OpenAIRE
- Journal :
- The Journal of biological chemistry
- Accession number :
- edsair.doi.dedup.....60d17ecb20e5d239c33659cd66e19c14