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Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
- Source :
- Immunity, Immunity, Elsevier, 2006, 25 (6), pp.989-1001. 〈10.1016/j.immuni.2006.10.011〉, Immunity, Elsevier, 2006, 25 (6), pp.989-1001. ⟨10.1016/j.immuni.2006.10.011⟩
- Publication Year :
- 2006
- Publisher :
- HAL CCSD, 2006.
-
Abstract
- SummaryAfter entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the paracortex, with each lymphocyte type showing apparently random migration within these distinct areas. Other than chemokines, the factors contributing to this spatial segregation and to the observed patterns of lymphocyte movement are poorly characterized. By combining confocal, electron, and intravital microscopy, we showed that the fibroblastic reticular cell network regulated naive T cell access to the paracortex and also supported and defined the limits of T cell movement within this domain, whereas a distinct follicular dendritic cell network similarly served as the substratum for movement of follicular B cells. These results highlight the central role of stromal microanatomy in orchestrating cell migration within the LN.
- Subjects :
- Pathology
Adoptive cell transfer
Lymphocyte
MESH : Immunohistochemistry
MESH : Diagnostic Imaging
MESH : Lymphocytes
MESH: Chemotaxis, Leukocyte
MESH: Lymph Nodes
Cell Communication
Mice
0302 clinical medicine
Reticular cell
MESH: Microscopy, Confocal
Immunology and Allergy
[ SDV.IMM ] Life Sciences [q-bio]/Immunology
MESH: Animals
Lymphocytes
MESH : Lymph Nodes
0303 health sciences
Microscopy, Confocal
MESH : Adoptive Transfer
Cell migration
MESH : Chemotaxis, Leukocyte
Adoptive Transfer
Immunohistochemistry
Cell biology
Chemotaxis, Leukocyte
medicine.anatomical_structure
Infectious Diseases
MESH : Microscopy, Electron, Transmission
MESH: Microscopy, Electron, Transmission
[SDV.IMM]Life Sciences [q-bio]/Immunology
Diagnostic Imaging
MESH : Microscopy, Electron, Scanning
medicine.medical_specialty
Stromal cell
Naive T cell
MESH: Microscopy, Electron, Scanning
MESH : Cell Communication
T cell
Immunology
MESH : Mice, Inbred C57BL
Biology
03 medical and health sciences
Microscopy, Electron, Transmission
MESH: Mice, Inbred C57BL
MESH: Cell Communication
MESH : Mice
medicine
Animals
MESH : Microscopy, Confocal
MESH: Mice
030304 developmental biology
Follicular dendritic cells
MESH: Diagnostic Imaging
MESH: Immunohistochemistry
Mice, Inbred C57BL
MESH: Adoptive Transfer
CELLIMMUNO
MESH : Stromal Cells
Microscopy, Electron, Scanning
CELLBIO
MESH: Lymphocytes
Lymph Nodes
MESH : Animals
Stromal Cells
MESH: Stromal Cells
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Database :
- OpenAIRE
- Journal :
- Immunity, Immunity, Elsevier, 2006, 25 (6), pp.989-1001. 〈10.1016/j.immuni.2006.10.011〉, Immunity, Elsevier, 2006, 25 (6), pp.989-1001. ⟨10.1016/j.immuni.2006.10.011⟩
- Accession number :
- edsair.doi.dedup.....60c624438eeb8152c30c8e4e89baf7f4