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Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
- Source :
- Cell. (2):367-380
- Publisher :
- Elsevier Inc.
-
Abstract
- SummaryIntestinal Th17 cells are induced and accumulate in response to colonization with a subgroup of intestinal microbes such as segmented filamentous bacteria (SFB) and certain extracellular pathogens. Here, we show that adhesion of microbes to intestinal epithelial cells (ECs) is a critical cue for Th17 induction. Upon monocolonization of germ-free mice or rats with SFB indigenous to mice (M-SFB) or rats (R-SFB), M-SFB and R-SFB showed host-specific adhesion to small intestinal ECs, accompanied by host-specific induction of Th17 cells. Citrobacter rodentium and Escherichia coli O157 triggered similar Th17 responses, whereas adhesion-defective mutants of these microbes failed to do so. Moreover, a mixture of 20 bacterial strains, which were selected and isolated from fecal samples of a patient with ulcerative colitis on the basis of their ability to cause a robust induction of Th17 cells in the mouse colon, also exhibited EC-adhesive characteristics.
- Subjects :
- Immunoglobulin A
Segmented filamentous bacteria
Cell
Mice, Inbred Strains
Biology
medicine.disease_cause
Escherichia coli O157
General Biochemistry, Genetics and Molecular Biology
Article
Bacterial Adhesion
Microbiology
Feces
Mice
Intestinal mucosa
Species Specificity
Citrobacter rodentium
medicine
Extracellular
Animals
Humans
Intestinal Mucosa
Escherichia coli
Escherichia coli Infections
Biochemistry, Genetics and Molecular Biology(all)
Enterobacteriaceae Infections
Epithelial Cells
Adhesion
Bacterial Infections
Rats, Inbred F344
Rats
Mice, Inbred C57BL
medicine.anatomical_structure
biology.protein
Microscopy, Electron, Scanning
Th17 Cells
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....60c3bc361bf6f462619d1d7e8f9d7b00
- Full Text :
- https://doi.org/10.1016/j.cell.2015.08.058