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Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein Cholesterol: A Mediation Analysis
- Source :
- Hypertension (Dallas, Tex. : 1979). 71(3)
- Publication Year :
- 2017
-
Abstract
- Central blood pressure may be a better predictor of cardiovascular disease than brachial pressure. Although statins reduce brachial pressure, their impact on central pressure remains unknown. Furthermore, whether this effect is mediated through a decrease in low-density lipoprotein cholesterol (LDL-c) is unknown. This study aims to characterize the association of statins and LDL-c with central and brachial blood pressures and to quantify their respective effects. Of the 20 004 CARTaGENE participants, 16 507 had available central blood pressure, LDL-c, and Framingham risk score. Multivariate analyses were used to evaluate the association between central pressure and LDL-c in subjects with or without statins. The impact of LDL-c on the association between statin and pressure parameters was determined through mediation analyses. LDL-c was positively associated with systolic and diastolic central pressure in nonusers (β=0.077 and 0.106; P P P P
- Subjects :
- Adult
Male
medicine.medical_specialty
Statin
medicine.drug_class
Diastole
Pulsatile flow
030204 cardiovascular system & hematology
Risk Assessment
Severity of Illness Index
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Severity of illness
Internal Medicine
medicine
Secondary Prevention
Humans
Ankle Brachial Index
030212 general & internal medicine
Aged
Analysis of Variance
Framingham Risk Score
business.industry
Quebec
Blood Pressure Determination
Cholesterol, LDL
Middle Aged
Prognosis
Pulse pressure
Primary Prevention
Blood pressure
Cross-Sectional Studies
Treatment Outcome
chemistry
Cardiovascular Diseases
Low-density lipoprotein
Hypertension
Cardiology
lipids (amino acids, peptides, and proteins)
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Subjects
Details
- ISSN :
- 15244563
- Volume :
- 71
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Accession number :
- edsair.doi.dedup.....60c33907f2eb7657adfbab676980a68f