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Non-invasive quantification of collagen turnover in renal transplant recipients

Authors :: Peter Olinga
Morten A. Karsdal
Stephan J. L. Bakker
Signe Holm Nielsen
Elisabeth G. D. Stribos
Harry van Goor
Federica Genovese
Henricus A. M. Mutsaers
Susanne Brix
Marc A. Seelen
Groningen Institute for Organ Transplantation (GIOT)
Groningen Kidney Center (GKC)
Lifestyle Medicine (LM)
Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
Pharmaceutical Technology and Biopharmacy
Metze, Konradin
Source :: PLoS ONE, 12(4):e0175898. PUBLIC LIBRARY SCIENCE, Stribos, E G D, Nielsen, S H, Brix, S, Karsdal, M A, Seelen, M A, van Goor, H, Bakker, S J L, Olinga, P, Mutsaers, H A M & Genovese, F 2017, ' Non-invasive quantification of collagen turnover in renal transplant recipients ', PLOS ONE, vol. 12, no. 4, pp. e0175898 . https://doi.org/10.1371/journal.pone.0175898, PLoS ONE, PLoS ONE, Vol 12, Iss 4, p e0175898 (2017), Stribos, E G D, Nielsen, S H, Pedersen, S B, Karsdal, M A, Seelen, M A, van Goor, H, Bakker, S J L, Olinga, P, Mutsaers, H A M, Genovese, F & Metze, K (ed.) 2017, ' Non-invasive quantification of collagen turnover in renal transplant recipients ', P L o S One, vol. 12, no. 4, e0175898 . https://doi.org/10.1371/journal.pone.0175898
Publication Year :: 2017
Abstract: Kidney allograft failure due to chronic injury/rejection remains the main cause of graft loss in renal transplant recipients (RTR). Here, we investigated whether specific biomarkers of extracellular matrix (ECM) turnover are associated with allograft function and chronic kidney disease (CKD) stage in RTR. Seventy-eight patients who attended the University Medical Center Groningen for a routine check-up after kidney transplantation were enrolled in the study. Plasma and/or 24h-urine samples were collected and specific matrix-metalloproteinase- generated neo-epitope fragments of collagens were measured by enzyme-linked immunosorbent assay. Our results demonstrated that urinary levels of C3M, a marker for collagen type III degradation, correlated with estimated glomerular filtration rate (eGFR; r = 0.58, p